extra=6 May 1824 – 14 August 1858 was the 13th shōgun of the Tokugawa shogunate of Japan. He held office for five years from 1853 to 1858. He was physically weak and was therefore considered by later historians to have been unfit to be shōgun.Ravina, Mark. (2004). The Last Samurai: The Life and Battles of Saigo Takamori, pp. 62–63. His reign marks the beginning of the Bakumatsu period.
On 4–7 November 1854, the Great Nankaidō and killed 80,000 people. This was followed by the 1854 Tōkai earthquake on 23 December 1854. The earthquake struck primarily in the Tōkai region but destroyed houses as far away as in Edo. The accompanying tsunami caused damage along the entire coast from the Bōsō Peninsula in modern-day Chiba Prefecture to Tosa Province (modern-day Kōchi Prefecture)._____. (2007). Ansei Daijishin in Ō-Edo Rekishi Hyakka, p. 253. The earthquake and tsunami also struck Shimoda on Izu peninsula; and because the port had just been designated as the prospective location for a U.S. consulate, some construed the natural disasters as demonstration of the displeasure of the kami.Hammer, Joshua. (2006). Yokohama Burning: the Deadly 1923 Earthquake and Fire that Helped Forge the Path to World War II, p.65.
The 1854 Nankai earthquake followed on 24 December 1854, killing over 10,000 people from the Tōkai region down to Kyushu, and the 1855 earthquake in Edo, one of the Ansei great earthquakes, with resulting fire damage and loss of life. Smitts, Gregory. "Shaking up Japan: Edo Society and the 1855 Catfish Picture Prints" , Journal of Social History, No 39, No. 4, Summer 2006. "Significant Earthquake Database" U.S. National Oceanic and Atmospheric Administration (NOAA), National Geophysical Data Center (NGDC)
On 18 December 1856, he married Princess Atsu, adopted daughter of Shimazu Nariakira and Konoe Tadahiro. She was known as Midaidokoro Atsuko (first-wife Atsuko).
On 21 October 1857, Iesada received the newly arrived American Consul Townsend Harris in an audience at Edo Castle.
Under Hotta Masayoshi's advice, Iesada ultimately signed the Harris Treaty of 1858 (the Treaty of Amity and Commerce between Japan and the United States),Beasley, William G. (1955). Select Documents on Japanese Foreign Policy, 1853–1868, p. 322. and subsequently other Unequal Treaties (including the Anglo-Japanese Friendship Treaty, and Anglo-Japanese Treaty of Amity and Commerce) which broke the sakoku (isolation) policy and opened Japan to foreign influences.
Kōmei, the reigning emperor at the time, was a major opponent of his policies. This strengthened the sonnō jōi movement.
Ii Naosuke was appointed tairō from 23 April 1858.
A widespread cholera outbreak from 1858 to 1860 is believed to have killed between 100,000 and 200,000 people in Edo alone." Local agrarian societies in colonial India: Japanese perspectives.". Kaoru Sugihara, Peter Robb, Haruka Yanagisawa (1996). p 313. Iesada died childless in 1858, possibly from the cholera outbreak. His grave is at the Tokugawa clan temple of Kan'ei-ji in Ueno. His buddhist name was Onkyoin.
Political factions within the bakufu clashed over the succession.Jansen, Marius B. and John Whitney Hall, eds. (1989). The Cambridge History of Japan, p. 316. Tokugawa Nariaki of Mito Domain, Satsuma and others wanted to see Tokugawa Yoshinobu as his successor, while the Ōoku and shogunate officials including Ii Naosuke supported Tokugawa Iemochi, and succeeded. These quarrels ended in the Ansei Purge.
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